E9. To be completed after lesson 22

---

Exercise 9.1

Why couldn’t we use scipy.optimize.least_squares() on the Singer data for mRNA counts from smFISH experiments?

Exercise 9.2

You may have heard that curve fitting involves “minimizing the sum of the square of the residuals.” If indeed finding the MLE for the pertinent parameters is equivalent to minimizing the sum of the square of the residuals, what underlying assumptions are there in the statistical model?

Exercise 9.3

Did you read the solutions of the last homework?

Exercise 9.4

Write down any questions or points of confusion that you have.